KRTAP11-1

Across TCGA patient cohorts, KRTAP11-1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible KRTAP11-1-associated genes across cancer lineages are ACVRL1, Dvl3, and HER2. Each is linked with KRTAP11-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP11-1-to-partner and partner-to-KRTAP11-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by KRTAP11-1-low versus KRTAP11-1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP11-1→partner) and Y-score (partner→KRTAP11-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ACVRL1 →	-0.137	-2.459	.035	.020	3	2
LUAD	Dvl3 →	+0.214	+3.000	.003	.034	3	2
LUAD	HER2 →	+0.470	+2.459	.012	.020	3	1
LUAD	Heregulin →	-0.130	-2.425	.041	.020	3	1
LUAD	14-3-3_epsilon →	-0.129	-3.309	.007	.009	3	1
LUAD	AMPK_alpha →	-0.182	-3.584	.014	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ACVRL1 by KRTAP11-1 expression — LUAD

Explore this box plot interactively →