KRTAP10-11

Across TCGA patient cohorts, KRTAP10-11 mutation is significantly associated with the RNA expression of many other genes, with 1,404 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP10-11-associated genes across cancer lineages are MTCYBP45, SSR1P2, and POM121L12. Each is linked with KRTAP10-11 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRTAP10-11-to-partner and partner-to-KRTAP10-11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP45 grouped by KRTAP10-11-low versus KRTAP10-11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP10-11→partner) and Y-score (partner→KRTAP10-11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTCYBP45 →	+0.052	+2.669	<.001	.007	3	3
BRCA	SSR1P2 →	+0.063	+6.711	<.001	<.001	3	3
SARC	POM121L12 →	+0.060	+6.152	<.001	.001	3	3
SARC	SIGLEC24P →	+0.079	+6.152	<.001	.001	3	2
CESC	SNORD13P3 →	+0.693	+4.934	<.001	.002	3	2
CESC	MIR5089 →	+0.524	+4.551	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,404 associations by consensus.

MTCYBP45 by KRTAP10-11 expression — SKCM

Explore this box plot interactively →