Across TCGA cell cohorts, KRT6A mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KRT6A-associated genes across cancer lineages are IL26, ACER1, and HMX3. Each is linked with KRT6A in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT6A-to-partner and partner-to-KRT6A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT6A→partner) and Y-score (partner→KRT6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IL26 →	+0.068	+4.510	<.001	.003	3	1
LARGE_INTESTINE	ACER1 →	+0.082	+3.145	.001	.004	3	1
LARGE_INTESTINE	HMX3 →	+0.595	+3.531	<.001	.007	3	1
LARGE_INTESTINE	TEX46 →	+0.157	+3.497	.001	.004	3	1
LARGE_INTESTINE	TBC1D3 →	+0.057	+3.103	<.001	.004	3	1
LUNG_NSCLC_LUAD	AEBP2 →	+0.689	+3.352	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

KRT6A survival (RNA) · tumor vs normal (RNA) · all KRT6A data types