Across TCGA pan-cancer cohorts, KRT6A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KRT6A’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where KRT6A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRT6A is over-expressed in tumor, although a few such as BRCA and PRAD show the opposite, repressed pattern.
COAD, LUSC, and LUAD are the cancer types where KRT6A tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT6A RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.