KRT27

Across TCGA patient cohorts, KRT27 mutation is significantly associated with the RNA expression of many other genes, with 1,498 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT27-associated genes across cancer lineages are RNA5SP377, RNU6-314P, and RNU4-27P. Each is linked with KRT27 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT27-to-partner and partner-to-KRT27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP377 grouped by KRT27-low versus KRT27-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT27→partner) and Y-score (partner→KRT27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP377 →	+0.647	+5.888	<.001	.002	3	3
UCEC	RNU6-314P →	+0.287	+2.577	.001	<.001	3	3
LGG	RNU4-27P →	+0.260	+6.135	<.001	.002	3	3
LUSC	RNU6-1245P →	+0.785	+5.093	<.001	.008	3	3
LIHC	MRPS21P8 →	+0.222	+6.890	<.001	<.001	3	2
UCEC	MRPL39 →	+0.440	+2.346	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,498 associations by consensus.

RNA5SP377 by KRT27 expression — LUAD

Explore this box plot interactively →