KRT27

Across TCGA pan-cancer cohorts, KRT27 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated KRT27 data layer compared with 11 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KRT27 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRT27 expression acts as an unfavorable survival marker, although some lineages such as LIHC and ESCA show a favorable association.

KIRC, BLCA, and LIHC are the cancer types where KRT27 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.628	0.750	.004	57	view →
BLCA	OS	Median	II,III,IV	0.305	0.518	.007	45	view →
LIHC	OS	Tertile	All	0.789	0.623	.001	38	view →
ESCA	DFS	Quartile	III,IV	0.547	0.280	.032	27	view →
THYM	DFS	Median	All	0.967	0.651	.005	26	view →
STAD	DFS	Quartile	IV	1.000	0.123	.003	26	view →
SKCM	OS	Tertile	All	0.284	0.413	.001	24	view →
GBM	OS	Tertile	All	0.104	0.434	<.001	18	view →
LUAD	OS	Quartile	All	0.913	0.734	.003	13	view →
COAD	DFS	Tertile	II,III,IV	0.728	0.472	.027	12	view →
MESO	DFS	Median	All	0.301	0.197	.027	7	view →
KIRP	DFS	Median	All	0.901	0.806	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

KRT27–KIRC (DFS)

Open the KIRC breakdown →