KRT23

Across TCGA cell cohorts, KRT23 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT23-associated genes across cancer lineages are TSPY2, OR4F4, and ODF4. Each is linked with KRT23 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT23-to-partner and partner-to-KRT23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPY2 grouped by KRT23-low versus KRT23-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT23→partner) and Y-score (partner→KRT23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TSPY2 →	+0.041	+3.632	<.001	.003	3	1
LARGE_INTESTINE	OR4F4 →	+0.023	+5.009	<.001	<.001	3	1
LARGE_INTESTINE	ODF4 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	KRT73 →	+0.070	+3.196	<.001	.007	3	1
LARGE_INTESTINE	DCANP1 →	+0.015	+3.347	<.001	.005	3	1
LARGE_INTESTINE	TBC1D3 →	+0.066	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

TSPY2 by KRT23 expression — LARGE_INTESTINE

Explore this box plot interactively →