KRT23

Across TCGA pan-cancer cohorts, KRT23 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of KRT23’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KRT23 RNA is repressed in tumor relative to normal tissue. In most cancer types KRT23 is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where KRT23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−2.646	<.001	12	view →
COAD	Female	All	+4.381	<.001	10	view →
BLCA	Male	III,IV	+4.438	.014	8	view →
BRCA	Female	II,III,IV	−1.082	.001	8	view →
KICH	All	All	−0.991	<.001	8	view →
READ	Female	All	+6.480	<.001	7	view →
KIRC	Male	III,IV	−0.812	<.001	7	view →
UCEC	All	All	+2.649	<.001	6	view →
LIHC	All	II,III,IV	+2.191	.002	6	view →
LUSC	Male	All	+2.182	<.001	5	view →
STAD	All	All	+1.624	.002	4	view →
CHOL	All	All	+5.632	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

KRT23–HNSC

Open the HNSC breakdown →