Across TCGA patient cohorts, KREMEN1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KREMEN1-associated genes across cancer lineages are Di-Ras3, EGFR_pY1068, and A-Raf_pS299. Each is linked with KREMEN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KREMEN1-to-partner and partner-to-KREMEN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KREMEN1→partner) and Y-score (partner→KREMEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.146	-2.446	.014	.018	3	2
UCEC	EGFR_pY1068 →	-0.252	-3.169	.012	.018	3	1
UCEC	A-Raf_pS299 →	-0.146	-2.321	.002	.034	3	1
UCEC	ERK2 →	+0.246	+2.700	.001	.006	3	1
UCEC	Lck →	+0.231	+2.321	.004	.034	3	1
UCEC	MEK1 →	+0.410	+3.584	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

KREMEN1 survival (RNA) · tumor vs normal (RNA) · all KREMEN1 data types