Across TCGA cell cohorts, KREMEN1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KREMEN1-associated genes across cancer lineages are TNP1, MYL7, and AWAT2. Each is linked with KREMEN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KREMEN1-to-partner and partner-to-KREMEN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KREMEN1→partner) and Y-score (partner→KREMEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNP1 →	+0.160	+4.415	<.001	.007	3	1
SKIN	MYL7 →	+0.274	+3.345	.006	.007	3	1
SKIN	AWAT2 →	+0.036	+3.994	<.001	.002	3	1
SKIN	CPA5 →	+0.355	+3.626	.008	.006	3	1
SKIN	CPLX4 →	+0.019	+3.658	<.001	.005	3	1
SKIN	INSL5 →	+0.041	+3.882	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

KREMEN1 survival (RNA) · tumor vs normal (RNA) · all KREMEN1 data types