KRAS

Across TCGA patient cohorts, KRAS RNA expression is significantly associated with the protein abundance of many other proteins, with 11,749 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KRAS-associated proteins across cancer lineages are ADNP, WIZ, and PAXBP1. Each is linked with KRAS in more than 4 cancer types. Because this analysis shows association rather than direction, both KRAS-to-partner and partner-to-KRAS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KRAS versus ADNP in LSCC, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KRAS→partner) and Y-score (partner→KRAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADNP →	+0.421	+0.852	<.001	<.001	3	5
GBM	WIZ →	+0.239	+0.250	.009	.009	3	4
LSCC	PAXBP1 →	+0.235	+0.837	<.001	.001	3	4
GBM	PHF6 →	+0.314	+0.286	.001	.001	3	4
GBM	POGZ →	+0.264	+0.360	.009	.001	3	4
GBM	RBM14 →	+0.274	+0.370	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,749 associations by consensus.

KRAS vs ADNP — LSCC

Explore this scatter interactively →