KRAS

Across TCGA pan-cancer cohorts, KRAS RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KRAS’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KRAS RNA is repressed in tumor relative to normal tissue. In most cancer types KRAS is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, BRCA, and THCA are the cancer types where KRAS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRAS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.581	<.001	8	view →
BRCA	All	III,IV	+0.991	<.001	6	view →
THCA	All	All	−0.341	<.001	6	view →
CHOL	Male	All	+1.808	<.001	5	view →
LUAD	Male	All	+0.755	<.001	5	view →
LUSC	Female	All	+0.683	<.001	5	view →
HNSC	All	All	+0.516	.001	5	view →
KIRP	All	II,III,IV	+0.462	.021	5	view →
STAD	All	All	+0.794	.015	4	view →
LIHC	All	All	+0.390	.005	3	view →
READ	Female	All	−0.751	.002	2	view →
PAAD	All	All	+0.589	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KRAS–COAD

Open the COAD breakdown →