KRAS

Across TCGA pan-cancer cohorts, KRAS RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated KRAS data layer compared with 14 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher KRAS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRAS expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

CESC, KIRC, and ACC are the cancer types where KRAS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	III,IV	0.157	0.854	<.001	68	view →
KIRC	OS	Median	All	0.730	0.538	<.001	68	view →
ACC	OS	Tertile	All	0.592	0.894	<.001	67	view →
MESO	OS	Median	All	0.282	0.487	.001	54	view →
PAAD	OS	Median	All	0.294	0.677	<.001	50	view →
UVM	DFS	Tertile	III,IV	0.272	0.871	.001	48	view →
LUAD	OS	Quartile	All	0.152	0.509	.001	39	view →
HNSC	OS	Median	All	0.320	0.485	.008	24	view →
ESCA	DFS	Median	III,IV	0.313	0.542	.008	24	view →
SARC	OS	Quartile	All	0.751	0.958	.002	18	view →
LUSC	DFS	Quartile	II,III,IV	0.680	0.440	.011	17	view →
LIHC	OS	Median	II,III,IV	0.589	0.786	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

KRAS–CESC (DFS)

Open the CESC breakdown →