KRAS

Across TCGA patient cohorts, KRAS protein abundance is significantly associated with the RNA expression of many other genes, with 9,970 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KRAS-associated genes across cancer lineages are GRAP2, CSF2RB, and TCL1A. Each is linked with KRAS in more than 2 cancer types. Because this analysis shows association rather than direction, both KRAS-to-partner and partner-to-KRAS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KRAS versus GRAP2 in HNSC, with a Pearson correlation of -0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRAS→partner) and Y-score (partner→KRAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GRAP2 →	-0.764	-0.341	<.001	.003	3	2
HNSC	CSF2RB →	-0.963	-0.433	<.001	<.001	3	2
HNSC	TCL1A →	-0.893	-0.369	<.001	.003	3	2
PDAC	MYLK2 →	-0.907	-0.302	<.001	<.001	3	2
HNSC	CCM2L →	-0.389	-0.315	<.001	.003	3	2
HNSC	SAMHD1 →	-1.029	-0.374	<.001	.004	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,970 associations by consensus.

KRAS vs GRAP2 — HNSC

Explore this scatter interactively →