KRAS

Across TCGA patient cohorts, KRAS mutation is significantly associated with the RNA expression of many other genes, with 14,366 significant associations in total. PAAD shows the largest number of these associations.

The most reproducible KRAS-associated genes across cancer lineages are ARL11, EDF1, and DUSP4. Each is linked with KRAS in more than 7 cancer types. Because this analysis shows association rather than direction, both KRAS-to-partner and partner-to-KRAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARL11 grouped by KRAS-low versus KRAS-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRAS→partner) and Y-score (partner→KRAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ARL11 →	-0.643	-3.570	.002	.002	3	8
BLCA	EDF1 →	+0.510	+3.332	<.001	.005	3	7
CESC	DUSP4 →	+1.818	+2.700	<.001	.004	3	7
UCEC	DUSP6 →	+1.080	+2.431	<.001	<.001	3	7
PAAD	AOAH →	-0.863	-2.905	<.001	<.001	3	7
PAAD	RAB39A →	-0.404	-1.145	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,366 associations by consensus.

ARL11 by KRAS expression — CESC

Explore this box plot interactively →