KRAS

Across TCGA cell cohorts, KRAS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,260 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KRAS-associated GO terms across cancer lineages are Positive regulation of Ras protein signal transduction, G1/S transition of mitotic cell cycle, and Positive regulation of organelle assembly. Each is linked with KRAS in more than 13 cancer types. Because this analysis shows association rather than direction, both KRAS-to-partner and partner-to-KRAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of Ras protein signal transduction grouped by KRAS-low versus KRAS-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KRAS→partner) and Y-score (partner→KRAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of Ras protein signal transduction →	+0.151	+0.777	<.001	.002	3	14
SOFT_TISSUE	G1/S transition of mitotic cell cycle →	+0.063	+0.793	.003	.004	3	12
BLOOD_Myeloma	Positive regulation of organelle assembly →	+0.066	+1.561	<.001	.002	2	13
UPPER_AERODIGESTIVE_TRACT	Heterochromatin formation →	+0.076	+0.783	<.001	<.001	2	13
LUNG_NSCLC_LUSC	Regulation of microtubule-based process →	+0.063	+1.404	<.001	<.001	3	12
BLOOD_Myeloma	mRNA destabilization →	+0.056	+1.278	<.001	.003	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,260 associations by consensus.

Positive regulation of Ras protein signal transduction by KRAS expression — PANCREAS

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