KPTN

Across TCGA cell cohorts, KPTN mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KPTN-associated genes across cancer lineages are DYDC1, AADACL3, and C22orf31. Each is linked with KPTN in more than 1 cancer types. Because this analysis shows association rather than direction, both KPTN-to-partner and partner-to-KPTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DYDC1 grouped by KPTN-low versus KPTN-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPTN→partner) and Y-score (partner→KPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DYDC1 →	+0.146	+4.906	<.001	.006	3	1
OESOPHAGUS	AADACL3 →	+0.410	+4.906	<.001	.006	3	1
BLOOD_Leukemia	C22orf31 →	+0.033	+3.289	<.001	.009	3	1
BLOOD_Leukemia	GHRH →	+0.282	+4.359	<.001	<.001	3	1
BLOOD_Leukemia	RAMP3 →	+0.445	+4.556	<.001	<.001	3	1
BLOOD_Leukemia	POU3F4 →	+0.020	+3.475	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

DYDC1 by KPTN expression — OESOPHAGUS

Explore this box plot interactively →