KPNA3

Across TCGA patient cohorts, KPNA3 mutation is significantly associated with the RNA expression of many other genes, with 3,036 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KPNA3-associated genes across cancer lineages are DCP1A, TUBGCP5, and UBE2NL. Each is linked with KPNA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KPNA3-to-partner and partner-to-KPNA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCP1A grouped by KPNA3-low versus KPNA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPNA3→partner) and Y-score (partner→KPNA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DCP1A →	+0.470	+2.345	.002	.003	3	2
UCEC	TUBGCP5 →	+0.433	+2.169	<.001	<.001	3	2
UCEC	UBE2NL →	+0.265	+2.201	<.001	<.001	3	2
UCEC	MBIP →	+0.640	+2.534	<.001	<.001	3	2
UCEC	HOMER1 →	+0.605	+3.595	.001	.001	3	2
UCEC	USP12 →	+0.516	+2.523	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,036 associations by consensus.

DCP1A by KPNA3 expression — UCEC

Explore this box plot interactively →