KNCN

Across TCGA patient cohorts, KNCN mutation is significantly associated with the RNA expression of many other genes, with 428 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KNCN-associated genes across cancer lineages are HEATR3, SYVN1, and TSSK3. Each is linked with KNCN in more than 1 cancer types. Because this analysis shows association rather than direction, both KNCN-to-partner and partner-to-KNCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HEATR3 grouped by KNCN-low versus KNCN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNCN→partner) and Y-score (partner→KNCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HEATR3 →	+0.593	+3.364	.004	.004	3	1
UCEC	SYVN1 →	+0.412	+3.480	.004	.002	3	1
UCEC	TSSK3 →	+0.306	+3.370	<.001	.004	3	1
UCEC	PLIN1 →	+0.698	+3.502	<.001	.002	3	1
UCEC	DOLPP1 →	+0.560	+3.470	.009	.003	3	1
UCEC	ZSWIM1 →	+0.434	+3.338	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 428 associations by consensus.

HEATR3 by KNCN expression — UCEC

Explore this box plot interactively →