KNCN

Across TCGA pan-cancer cohorts, KNCN RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated KNCN data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KNCN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KNCN expression acts as an unfavorable survival marker, although some lineages such as SCLC and PAAD show a favorable association.

KIRC, ACC, and SCLC are the cancer types where KNCN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	III,IV	0.186	0.522	.001	56	view →
ACC	OS	Tertile	All	0.114	0.892	<.001	54	view →
SCLC	DFS	Tertile	II,III,IV	0.820	0.326	<.001	29	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	27	view →
STAD	DFS	Tertile	IV	0.137	0.565	.005	18	view →
THCA	DFS	Tertile	IV	0.219	0.810	<.001	18	view →
LIHC	DFS	Tertile	II,III,IV	0.107	0.476	.001	18	view →
SKCM	DFS	Tertile	IV	0.045	0.471	.016	15	view →
KIRP	DFS	Tertile	All	0.273	0.650	<.001	9	view →
TGCT	DFS	Quartile	All	0.453	0.742	.009	8	view →
PAAD	OS	Tertile	All	0.716	0.577	.032	6	view →
GBM	OS	Tertile	All	0.214	0.320	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

KNCN–KIRC (DFS)

Open the KIRC breakdown →