KMT5B

Across TCGA cell cohorts, KMT5B mutation is significantly associated with the RNA expression of many other genes, with 433 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KMT5B-associated genes across cancer lineages are DPRX, NANOGNB, and H2BW1. Each is linked with KMT5B in more than 1 cancer types. Because this analysis shows association rather than direction, both KMT5B-to-partner and partner-to-KMT5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by KMT5B-low versus KMT5B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT5B→partner) and Y-score (partner→KMT5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DPRX →	+0.328	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	NANOGNB →	+0.121	+4.887	<.001	.009	3	1
SKIN	H2BW1 →	+0.208	+4.977	<.001	.007	3	1
SKIN	CYLC1 →	+0.013	+5.415	<.001	.004	3	1
SKIN	FAM205C →	+0.045	+4.977	<.001	.007	3	1
SKIN	MEIKIN →	+0.022	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 433 associations by consensus.

DPRX by KMT5B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →