KMT5B

Across TCGA pan-cancer cohorts, KMT5B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated KMT5B data layer compared with 9 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher KMT5B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KMT5B expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

CESC, KIRC, and ACC are the cancer types where KMT5B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.662	0.817	<.001	98	view →
KIRC	OS	Tertile	All	0.730	0.526	<.001	88	view →
ACC	DFS	Median	All	0.402	0.753	<.001	65	view →
UCS	DFS	Median	IV	0.909	0.416	.008	30	view →
LUSC	DFS	Median	III,IV	0.225	0.522	.005	28	view →
THYM	DFS	Tertile	III,IV	1.000	0.243	.012	22	view →
LIHC	OS	Quartile	All	0.660	0.818	.004	15	view →
UCEC	DFS	Quartile	All	0.568	0.809	.008	14	view →
READ	DFS	Tertile	IV	0.364	0.843	.003	13	view →
BLCA	DFS	Median	All	0.564	0.467	.015	9	view →
LUAD	OS	Tertile	All	0.886	0.786	.018	9	view →
UVM	DFS	Tertile	III,IV	0.270	0.780	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

KMT5B–CESC (DFS)

Open the CESC breakdown →