Across TCGA patient cohorts, KMT5A RNA expression is significantly associated with the protein abundance of many other proteins, with 16,353 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KMT5A-associated proteins across cancer lineages are SRSF9, SBNO1, and SMC2. Each is linked with KMT5A in more than 7 cancer types. Because this analysis shows association rather than direction, both KMT5A-to-partner and partner-to-KMT5A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT5A→partner) and Y-score (partner→KMT5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SRSF9 →	+0.442	+0.700	<.001	<.001	3	8
LSCC	SBNO1 →	+0.327	+0.710	<.001	<.001	3	7
GBM	SMC2 →	+0.790	+0.420	<.001	<.001	3	6
GBM	SMC4 →	+0.746	+0.414	<.001	<.001	3	6
LSCC	ATAD2 →	+0.467	+0.533	<.001	<.001	3	6
OV	TMPO →	+0.341	+0.322	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,353 associations by consensus.

Exploration

KMT5A survival (RNA) · tumor vs normal (RNA) · all KMT5A data types