KMT2E

Across TCGA patient cohorts, KMT2E mutation is significantly associated with the RNA expression of many other genes, with 4,309 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMT2E-associated genes across cancer lineages are MRPL46, SENP3-EIF4A1, and ZCCHC9. Each is linked with KMT2E in more than 3 cancer types. Because this analysis shows association rather than direction, both KMT2E-to-partner and partner-to-KMT2E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL46 grouped by KMT2E-low versus KMT2E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2E→partner) and Y-score (partner→KMT2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL46 →	+0.253	+1.212	.001	.003	3	4
UCEC	SENP3-EIF4A1 →	+0.097	+1.974	<.001	.001	3	4
SKCM	ZCCHC9 →	+0.621	+2.813	.002	.001	3	4
COAD	MRPL22 →	+0.582	+3.652	<.001	.001	3	4
UCEC	ENTR1 →	+0.300	+2.021	.001	<.001	3	4
UCEC	SEC11C →	+0.438	+2.091	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,309 associations by consensus.

MRPL46 by KMT2E expression — UCEC

Explore this box plot interactively →