KMT2E

Across TCGA pan-cancer cohorts, KMT2E RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated KMT2E data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KMT2E RNA is associated with better overall survival. In most high-consensus cancer types, elevated KMT2E expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, KICH, and ACC are the cancer types where KMT2E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.709	0.543	<.001	72	view →
KICH	DFS	Tertile	III,IV	0.363	1.000	.001	50	view →
ACC	DFS	Median	All	0.401	0.755	<.001	44	view →
HNSC	DFS	Quartile	IV	0.417	0.225	.005	37	view →
CESC	DFS	Median	III,IV	0.598	0.859	.006	30	view →
KIRP	OS	Median	II,III,IV	0.494	0.926	.005	26	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
SKCM	DFS	Median	All	0.664	0.552	.003	19	view →
GBM	DFS	Median	All	0.383	0.196	.006	18	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.567	.009	16	view →
COAD	DFS	Median	All	0.382	0.618	.004	15	view →
ESCA	OS	Quartile	III,IV	0.770	0.461	.022	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

KMT2E–KIRC (OS)

Open the KIRC breakdown →