KMT2E

Across TCGA cell cohorts, KMT2E mutation is significantly associated with the mutation status of many other genes, with 3,463 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KMT2E-associated genes across cancer lineages are POU6F2, LRP1, and HECW2. Each is linked with KMT2E in more than 4 cancer types. Because this analysis shows association rather than direction, both KMT2E-to-partner and partner-to-KMT2E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POU6F2 grouped by KMT2E-low versus KMT2E-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2E→partner) and Y-score (partner→KMT2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	POU6F2 →	+3.660	+3.193	.006	.006	1	5
LUNG_NSCLC_LUAD	LRP1 →	+2.415	+4.108	.003	.003	1	5
BLOOD_Leukemia	HECW2 →	+2.316	+2.849	<.001	<.001	1	5
OVARY	FBXO38 →	+3.684	+3.217	.006	.006	1	5
LARGE_INTESTINE	TM9SF1 →	+2.479	+1.691	.008	.008	1	5
BREAST	GOLGA4 →	+4.297	+4.857	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,463 associations by consensus.

POU6F2 by KMT2E expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →