KMT2C

Across TCGA patient cohorts, KMT2C protein abundance is significantly associated with the RNA expression of many other genes, with 9,377 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KMT2C-associated genes across cancer lineages are PAXIP1, ZNF212, and TNPO3. Each is linked with KMT2C in more than 5 cancer types. Because this analysis shows association rather than direction, both KMT2C-to-partner and partner-to-KMT2C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KMT2C versus PAXIP1 in HNSC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2C→partner) and Y-score (partner→KMT2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PAXIP1 →	+0.516	+0.253	.001	.001	3	6
LSCC	ZNF212 →	+0.588	+0.258	<.001	<.001	3	6
HNSC	TNPO3 →	+0.633	+0.220	.001	.001	3	5
UCEC	MKRN1 →	+0.707	+0.216	.001	<.001	3	5
HNSC	ZNF282 →	+0.696	+0.202	<.001	.005	3	5
LSCC	NOM1 →	+0.567	+0.271	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,377 associations by consensus.

KMT2C vs PAXIP1 — HNSC

Explore this scatter interactively →