KMT2C

Across TCGA pan-cancer cohorts, KMT2C RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of KMT2C’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where KMT2C RNA is repressed in tumor relative to normal tissue. In most cancer types KMT2C is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, CHOL, and LIHC are the cancer types where KMT2C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KMT2C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.513	<.001	8	view →
CHOL	All	All	+1.221	<.001	5	view →
LIHC	Female	All	+0.695	<.001	5	view →
KIRP	All	IV	+0.754	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

KMT2C–THCA

Open the THCA breakdown →