KMT2C

Across TCGA pan-cancer cohorts, KMT2C RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated KMT2C data layer compared with 9 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KMT2C RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KMT2C expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and LUAD are the cancer types where KMT2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.774	0.641	.001	84	view →
KIRC	OS	Median	All	0.716	0.552	<.001	80	view →
LUAD	OS	Quartile	III,IV	0.728	0.277	<.001	66	view →
SCLC	DFS	Tertile	II,III,IV	0.803	0.366	<.001	41	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
CESC	DFS	Median	II,III,IV	0.703	0.870	.003	34	view →
LUSC	DFS	Quartile	III,IV	0.492	0.823	.006	22	view →
ACC	DFS	Median	IV	0.472	0.089	.012	22	view →
SKCM	DFS	Quartile	All	0.334	0.185	.005	19	view →
PAAD	DFS	Quartile	II,III,IV	0.337	0.550	.033	12	view →
DLBC	DFS	Tertile	All	0.631	1.000	.004	12	view →
CHOL	DFS	Median	All	0.609	0.203	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

KMT2C–HNSC (DFS)

Open the HNSC breakdown →