KMT2C

Across TCGA patient cohorts, KMT2C mutation is significantly associated with the total protein of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMT2C-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and IGFBP2. Each is linked with KMT2C in more than 5 cancer types. Because this analysis shows association rather than direction, both KMT2C-to-partner and partner-to-KMT2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KMT2C-low versus KMT2C-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2C→partner) and Y-score (partner→KMT2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.929	+2.338	<.001	.017	3	6
UCEC	Cyclin-B1 →	+0.472	+1.280	<.001	<.001	3	5
CESC	IGFBP2 →	-0.537	-3.000	.012	.029	3	4
SKCM	TFRC →	+0.498	+1.662	.005	.009	3	4
UCEC	ASNS →	+0.245	+1.129	.002	.005	3	4
UCEC	ATM →	-0.443	-1.184	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

Caspase-7-cleavedD198 by KMT2C expression — COAD

Explore this box plot interactively →