KMT2C

Across TCGA cell cohorts, KMT2C RNA expression is significantly associated with the go_rna of many other GO terms, with 5,336 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KMT2C-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Sperm motility, and Peptidyl-serine phosphorylation. Each is linked with KMT2C in more than 17 cancer types. Because this analysis shows association rather than direction, both KMT2C-to-partner and partner-to-KMT2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by KMT2C-low versus KMT2C-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2C→partner) and Y-score (partner→KMT2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.162	+0.888	<.001	<.001	3	18
OESOPHAGUS	Sperm motility →	-0.105	-0.781	.002	.003	3	16
PANCREAS	Peptidyl-serine phosphorylation →	+0.068	+0.799	.007	.006	3	16
PANCREAS	Peptidyl-serine modification →	+0.069	+0.833	.006	.004	3	16
BONE	Pre-mRNA catabolic process →	+0.202	+0.907	<.001	<.001	3	16
LUNG_SCLC	Negative regulation of gene expression, epigenetic →	+0.082	+1.072	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,336 associations by consensus.

Negative regulation of chromosome condensation by KMT2C expression — SOFT_TISSUE

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