KMT2C

Across TCGA cell cohorts, KMT2C mutation is significantly associated with the RNA expression of many other genes, with 1,633 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KMT2C-associated genes across cancer lineages are PWWP3A, E2F2, and EWSR1. Each is linked with KMT2C in more than 3 cancer types. Because this analysis shows association rather than direction, both KMT2C-to-partner and partner-to-KMT2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PWWP3A grouped by KMT2C-low versus KMT2C-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2C→partner) and Y-score (partner→KMT2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PWWP3A →	+0.779	+3.169	.004	.009	3	4
STOMACH	E2F2 →	+0.881	+3.381	.009	.002	3	4
BREAST	EWSR1 →	+0.515	+2.635	.002	.002	3	4
BLOOD_Lymphoma	KPTN →	+0.591	+3.376	.005	.002	3	4
OVARY	TRNAU1AP →	+0.457	+2.115	.003	.007	3	4
LARGE_INTESTINE	CEP85 →	+0.601	+1.566	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,633 associations by consensus.

PWWP3A by KMT2C expression — SOFT_TISSUE

Explore this box plot interactively →