KMT2A

Across TCGA cell cohorts, KMT2A mutation is significantly associated with the RNA expression of many other genes, with 707 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KMT2A-associated genes across cancer lineages are KRTAP4-9, DENND10, and PRR30. Each is linked with KMT2A in more than 2 cancer types. Because this analysis shows association rather than direction, both KMT2A-to-partner and partner-to-KMT2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-9 grouped by KMT2A-low versus KMT2A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2A→partner) and Y-score (partner→KMT2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP4-9 →	+0.407	+2.906	.001	.008	3	3
BLOOD_Leukemia	DENND10 →	+0.752	+2.411	.004	.001	3	3
BLOOD_Leukemia	PRR30 →	+0.008	+2.305	<.001	.002	3	3
BLOOD_Leukemia	ZNF286A →	+1.001	+2.380	.002	.008	3	3
CNS	TEC →	+0.650	+3.220	<.001	.005	3	3
PANCREAS	ACTRT1 →	+0.010	+3.554	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 707 associations by consensus.

KRTAP4-9 by KMT2A expression — SOFT_TISSUE

Explore this box plot interactively →