KMT2A

Across TCGA pan-cancer cohorts, KMT2A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated KMT2A data layer compared with 10 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher KMT2A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KMT2A expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

ACC, KIRC, and HNSC are the cancer types where KMT2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.267	0.639	<.001	82	view →
KIRC	DFS	Median	All	0.708	0.542	<.001	80	view →
HNSC	DFS	Tertile	IV	0.794	0.569	.002	64	view →
MESO	OS	Median	III,IV	0.295	0.469	.014	61	view →
UCS	OS	Median	II,III,IV	0.614	0.242	.009	58	view →
KICH	OS	Tertile	All	0.726	1.000	.007	35	view →
LGG	OS	Median	All	0.945	0.825	<.001	32	view →
LIHC	OS	Median	All	0.705	0.854	.002	30	view →
SKCM	OS	Quartile	III,IV	0.590	0.222	<.001	24	view →
THYM	DFS	Tertile	II,III,IV	0.896	0.564	.004	22	view →
KIRP	OS	Tertile	III,IV	0.304	0.635	.023	20	view →
CHOL	DFS	Median	All	0.605	0.249	.010	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

KMT2A–ACC (DFS)

Open the ACC breakdown →