KLRC4-KLRK1

Across TCGA patient cohorts, KLRC4-KLRK1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible KLRC4-KLRK1-associated genes across cancer lineages are IGFBP2, MIG-6, and mTOR. Each is linked with KLRC4-KLRK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLRC4-KLRK1-to-partner and partner-to-KLRC4-KLRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by KLRC4-KLRK1-low versus KLRC4-KLRK1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLRC4-KLRK1→partner) and Y-score (partner→KLRC4-KLRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IGFBP2 →	-0.660	-3.321	.005	.009	3	1
SKCM	MIG-6 →	+0.167	+3.025	.023	.018	3	1
SKCM	mTOR →	+0.224	+2.584	.044	.011	3	1
SKCM	c-Met →	+0.158	+3.033	.020	.017	3	1
UCEC	Caspase-8 →	-0.308	-3.000	.034	.037	3	1
SKCM	PKC-a_pS657 →	-0.359	-2.987	.045	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

IGFBP2 by KLRC4-KLRK1 expression — SKCM

Explore this box plot interactively →