KLRC4-KLRK1

Across TCGA pan-cancer cohorts, KLRC4-KLRK1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of KLRC4-KLRK1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where KLRC4-KLRK1 RNA is repressed in tumor relative to normal tissue. In most cancer types KLRC4-KLRK1 is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

LUSC, KIRC, and BRCA are the cancer types where KLRC4-KLRK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLRC4-KLRK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.266	<.001	8	view →
KIRC	Male	II,III,IV	+0.249	<.001	8	view →
BRCA	All	III,IV	−0.160	.008	6	view →
THCA	All	All	−0.170	.001	4	view →
READ	All	II,III,IV	−0.240	.020	3	view →
UCEC	All	All	−0.133	.007	2	view →
KICH	All	All	−0.077	.037	2	view →
STAD	All	II,III,IV	+0.145	.040	1	view →
LUAD	Female	II,III,IV	−0.128	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

KLRC4-KLRK1–LUSC

Open the LUSC breakdown →