KLRC4-KLRK1

Across TCGA pan-cancer cohorts, KLRC4-KLRK1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated KLRC4-KLRK1 data layer compared with 5 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher KLRC4-KLRK1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KLRC4-KLRK1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and BRCA are the cancer types where KLRC4-KLRK1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.431	0.252	<.001	107	view →
HNSC	DFS	Median	All	0.757	0.635	<.001	101	view →
BRCA	DFS	Tertile	III,IV	0.715	0.335	<.001	69	view →
BLCA	OS	Tertile	III,IV	0.479	0.246	.003	66	view →
ACC	OS	Quartile	II,III,IV	0.670	0.937	<.001	43	view →
LIHC	OS	Median	All	0.785	0.614	<.001	43	view →
SCLC	DFS	Median	IV	0.651	0.148	.006	37	view →
LGG	OS	Median	All	0.864	0.753	<.001	35	view →
CESC	OS	Median	All	0.857	0.734	.006	30	view →
THCA	DFS	Median	II,III,IV	0.882	0.539	.007	26	view →
KIRP	OS	Tertile	All	0.561	0.823	.002	22	view →
PAAD	OS	Median	II,III,IV	0.482	0.296	.002	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

KLRC4-KLRK1–SKCM (OS)

Open the SKCM breakdown →