KLK15

Across TCGA patient cohorts, KLK15 mutation is significantly associated with the RNA expression of many other genes, with 913 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK15-associated genes across cancer lineages are RPS28P5, MIR4794, and RPL13AP6. Each is linked with KLK15 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK15-to-partner and partner-to-KLK15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS28P5 grouped by KLK15-low versus KLK15-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK15→partner) and Y-score (partner→KLK15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPS28P5 →	+0.528	+3.385	.001	.004	3	3
GBM	MIR4794 →	+0.325	+4.273	<.001	.008	3	2
SKCM	RPL13AP6 →	+0.390	+2.816	.002	.001	3	2
COAD	ELOCP27 →	+0.676	+3.830	<.001	.005	3	2
UCEC	PRSS12 →	-1.131	-2.502	<.001	.002	3	2
UCEC	CENPN →	+0.813	+2.721	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 913 associations by consensus.

RPS28P5 by KLK15 expression — SKCM

Explore this box plot interactively →