KLK15

Across TCGA patient cohorts, KLK15 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK15-associated genes across cancer lineages are PDCD4, 4E-BP1, and PKC-delta_pS664. Each is linked with KLK15 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK15-to-partner and partner-to-KLK15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by KLK15-low versus KLK15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK15→partner) and Y-score (partner→KLK15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.615	-2.999	.003	.035	3	3
UCEC	4E-BP1 →	+0.352	+3.029	.003	.018	3	3
UCEC	PKC-delta_pS664 →	-0.135	-2.312	.012	.034	3	2
UCEC	Smad3 →	+0.143	+3.000	.035	.036	3	2
LUSC	4E-BP1_pS65 →	+0.236	+2.816	.010	.036	3	1
LUAD	PDK1 →	-0.129	-3.000	.033	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PDCD4 by KLK15 expression — UCEC

Explore this box plot interactively →