KLK15

Across TCGA cell cohorts, KLK15 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KLK15-associated genes across cancer lineages are DEFB108B, UNC93A, and CYP26C1. Each is linked with KLK15 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK15-to-partner and partner-to-KLK15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB108B grouped by KLK15-low versus KLK15-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK15→partner) and Y-score (partner→KLK15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DEFB108B →	+0.176	+5.781	<.001	.001	3	1
SKIN	UNC93A →	+0.098	+4.263	<.001	.002	3	1
SKIN	CYP26C1 →	+0.138	+3.906	.001	.005	3	1
LARGE_INTESTINE	OOSP4A →	+0.133	+3.793	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	CRYBB1 →	+0.021	+4.736	.003	.009	3	1
UPPER_AERODIGESTIVE_TRACT	RBMY1E →	+0.030	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

DEFB108B by KLK15 expression — BREAST

Explore this box plot interactively →