KLK14

Across TCGA patient cohorts, KLK14 protein abundance is significantly associated with the RNA expression of many other genes, with 5,775 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible KLK14-associated genes across cancer lineages are KLK12, PRR9, and LY6G6C. Each is linked with KLK14 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLK14-to-partner and partner-to-KLK14 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLK14 versus KLK12 in LUAD, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK14→partner) and Y-score (partner→KLK14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KLK12 →	+2.547	+1.082	.005	.006	3	5
UCEC	PRR9 →	+3.889	+1.456	.001	<.001	3	3
UCEC	LY6G6C →	+4.123	+1.632	<.001	<.001	3	3
PDAC	PIP5K1B →	-1.250	-0.981	<.001	.001	3	2
HNSC	FAM189A2 →	-0.481	-0.986	.006	.001	3	2
HNSC	FAM171A1 →	-0.634	-0.938	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,775 associations by consensus.

KLK14 vs KLK12 — LUAD

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