KLK14

Across TCGA pan-cancer cohorts, KLK14 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KLK14’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where KLK14 RNA is repressed in tumor relative to normal tissue. In most cancer types KLK14 is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

BRCA, KIRC, and LUSC are the cancer types where KLK14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLK14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−1.229	<.001	6	view →
KIRC	All	All	+0.094	.001	5	view →
LUSC	Male	All	+1.140	<.001	4	view →
LUAD	Female	All	−1.094	<.001	4	view →
KICH	All	II,III,IV	+0.208	.017	4	view →
HNSC	All	All	+1.177	.017	3	view →
UCEC	All	All	+1.485	<.001	2	view →
CHOL	All	All	+0.976	.001	2	view →
PRAD	All	All	+0.646	.020	2	view →
THCA	Male	III,IV	−0.230	.027	2	view →
BLCA	All	IV	−0.674	.034	1	view →
KIRP	Female	All	+0.260	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KLK14–BRCA

Open the BRCA breakdown →