KLK1

Across TCGA patient cohorts, KLK1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,325 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible KLK1-associated proteins across cancer lineages are THUMPD3, GOLPH3L, and MLLT1_S475. Each is linked with KLK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK1-to-partner and partner-to-KLK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLK1 versus THUMPD3 in BRCA, with a Pearson correlation of -0.26.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK1→partner) and Y-score (partner→KLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THUMPD3 →	-0.279	-0.661	.002	.009	3	3
COAD	GOLPH3L →	+0.342	+1.118	<.001	.002	3	3
PDAC	MLLT1_S475 →	+0.270	+2.183	.002	.007	3	3
BRCA	PIK3AP1 →	+0.458	+0.729	<.001	.002	3	3
BRCA	STUB1 →	-0.458	-0.696	.003	.004	3	3
BRCA	SYDE2_S104 →	-0.445	-0.556	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,325 associations by consensus.

KLK1 vs THUMPD3 — BRCA

Explore this scatter interactively →