KLK1

Across TCGA pan-cancer cohorts, KLK1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KLK1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where KLK1 RNA is repressed in tumor relative to normal tissue. In most cancer types KLK1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and COAD are the cancer types where KLK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	All	−4.026	<.001	11	view →
KIRC	Male	All	−3.536	<.001	11	view →
COAD	Female	All	−1.575	<.001	9	view →
KICH	Female	II,III,IV	+5.402	<.001	8	view →
THCA	Male	III,IV	−2.191	<.001	8	view →
BRCA	Female	II,III,IV	−0.431	<.001	6	view →
UCEC	All	II,III,IV	−1.271	.021	4	view →
LUSC	All	All	+0.773	<.001	4	view →
BLCA	All	III,IV	−0.654	.011	3	view →
LUAD	Female	III,IV	−0.630	.009	3	view →
STAD	Male	All	+1.324	.022	2	view →
READ	Female	All	−0.906	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

KLK1–KIRP

Open the KIRP breakdown →