KLHL5

Across TCGA cell cohorts, KLHL5 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible KLHL5-associated genes across cancer lineages are ASB17, AGRP, and DEFA5. Each is linked with KLHL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL5-to-partner and partner-to-KLHL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by KLHL5-low versus KLHL5-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL5→partner) and Y-score (partner→KLHL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.011	+3.807	<.001	.009	3	1
OVARY	AGRP →	+0.076	+3.825	<.001	.006	3	1
OVARY	DEFA5 →	+0.068	+3.405	.001	.005	3	1
OVARY	TAS2R39 →	+0.019	+3.405	<.001	.005	3	1
BLOOD_Lymphoma	CALHM4 →	+0.378	+4.350	<.001	.005	3	1
BLOOD_Leukemia	TRPM3 →	+0.074	+4.295	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ASB17 by KLHL5 expression — OVARY

Explore this box plot interactively →