KLHL5

Across TCGA pan-cancer cohorts, KLHL5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KLHL5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KLHL5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLHL5 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, LIHC, and KICH are the cancer types where KLHL5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHL5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.873	<.001	12	view →
LIHC	Female	II,III,IV	+1.484	<.001	9	view →
KICH	Female	All	−1.573	<.001	7	view →
LUAD	Male	II,III,IV	+1.088	<.001	6	view →
LUSC	All	II,III,IV	+0.826	<.001	6	view →
KIRP	Male	All	−0.710	<.001	5	view →
CHOL	All	All	+1.508	<.001	3	view →
UCEC	All	All	−0.771	.007	2	view →
PRAD	All	All	−0.664	<.001	2	view →
READ	Female	All	−2.058	.018	1	view →
BLCA	Male	IV	−1.615	.023	1	view →
ESCA	All	All	+0.982	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KLHL5–HNSC

Open the HNSC breakdown →