KLHL41

Across TCGA patient cohorts, KLHL41 mutation is significantly associated with the RNA expression of many other genes, with 1,047 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL41-associated genes across cancer lineages are MTCO2P20, RNU6ATAC30P, and RAB42P1. Each is linked with KLHL41 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL41-to-partner and partner-to-KLHL41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO2P20 grouped by KLHL41-low versus KLHL41-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL41→partner) and Y-score (partner→KLHL41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MTCO2P20 →	+0.095	+5.039	<.001	.008	3	2
BRCA	RNU6ATAC30P →	+0.589	+5.231	<.001	.001	3	2
LIHC	RAB42P1 →	+0.133	+5.447	<.001	.005	3	2
SKCM	LINC02374 →	+0.041	+5.867	<.001	.003	3	2
UCEC	RN7SL134P →	+0.169	+2.599	<.001	<.001	3	2
UCEC	LINC01670 →	+0.073	+1.843	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,047 associations by consensus.

MTCO2P20 by KLHL41 expression — READ

Explore this box plot interactively →