KLHL41

Across TCGA pan-cancer cohorts, KLHL41 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KLHL41’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where KLHL41 RNA is repressed in tumor relative to normal tissue. In most cancer types KLHL41 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and LUAD are the cancer types where KLHL41 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHL41 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−4.027	<.001	11	view →
KICH	Female	All	−0.477	<.001	10	view →
LUAD	Female	III,IV	−0.916	<.001	9	view →
HNSC	Male	All	−2.901	.003	8	view →
LUSC	All	III,IV	−1.138	<.001	8	view →
KIRP	All	III,IV	−0.190	.003	6	view →
THCA	All	II,III,IV	−0.579	.005	5	view →
KIRC	Female	IV	−0.180	.026	3	view →
PRAD	All	All	−0.840	.009	2	view →
STAD	All	All	−0.595	.019	2	view →
LIHC	All	All	+0.097	.031	2	view →
CHOL	All	All	+0.234	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KLHL41–BLCA

Open the BLCA breakdown →