KLHL41

Across TCGA pan-cancer cohorts, KLHL41 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated KLHL41 data layer compared with 5 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher KLHL41 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLHL41 expression acts as an unfavorable survival marker, although some lineages such as READ and LUAD show a favorable association.

STAD, UVM, and HNSC are the cancer types where KLHL41 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	III,IV	0.341	0.619	<.001	105	view →
UVM	DFS	Tertile	All	0.329	0.816	<.001	93	view →
HNSC	OS	Median	All	0.713	0.820	.001	66	view →
LGG	DFS	Median	All	0.651	0.815	<.001	48	view →
READ	DFS	Tertile	II,III,IV	0.899	0.724	.001	39	view →
LUAD	OS	Tertile	All	0.466	0.301	.004	27	view →
PAAD	DFS	Median	All	0.378	0.191	.002	27	view →
BRCA	OS	Quartile	III,IV	0.884	0.723	.009	24	view →
KIRC	DFS	Tertile	All	0.941	0.816	.023	16	view →
KIRP	DFS	Tertile	All	0.957	0.741	.018	14	view →
UCS	DFS	Quartile	II,III,IV	0.690	0.199	.007	14	view →
SCLC	DFS	Tertile	All	0.486	0.745	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

KLHL41–STAD (DFS)

Open the STAD breakdown →