KLHL41

Across TCGA patient cohorts, KLHL41 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL41-associated genes across cancer lineages are p62 Lck ligand, A-Raf_pS299, and FOXO3a_pS318_S321. Each is linked with KLHL41 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL41-to-partner and partner-to-KLHL41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by KLHL41-low versus KLHL41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL41→partner) and Y-score (partner→KLHL41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.404	+3.321	.003	.009	3	2
UCEC	A-Raf_pS299 →	-0.132	-2.459	.009	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.105	-2.575	.048	.010	3	1
UCEC	Gab2 →	+0.344	+1.700	.023	.044	3	1
UCEC	ACC1 →	+0.340	+2.820	.027	.035	3	1
UCEC	Heregulin →	-0.121	-3.156	.020	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

p62 Lck ligand by KLHL41 expression — UCEC

Explore this box plot interactively →